Publications

Prospective Randomized Comparison of OnabotulinumtoxinA (Botox) and AbobotulinumtoxinA (Dysport) in the Treatment of Forehead, Glabellar, and Periorbital Wrinkles

By December 28, 2012 February 19th, 2013 No Comments

Botulinum toxin A, a neurotoxic protein produced by Clostridium botulinum, is being utilized by clinicians to decrease muscle hyperactivity for a multitude of therapeutic and cosmetic symptoms ranging from cervical dystonia to glabellar rhytids. Its use accounted for more than 25% of nonsurgical aesthetic procedures in the United States in 2008.1 There are eight serotypes of the toxin, synthesized as a single-chain polypeptide protoxin and “nicked” by proteases to activate binding at nerve terminal receptors. Once bound to synaptic receptor SNAP-25, the toxin inhibits release of acetylcholine, thus causing muscle paralysis.

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